Define: enzyme surgical instrument cleaning detergents
Surgical Instrument Cleaners
4 enzyme detergent surgical instrument cleaners are designed for thoroughly cleaning surgical instrument cleaner in less cleaning time and at a lower cost. The use of enzymes of various compositions and concentrations, in surgical instrument detergents is becoming common. Over half of all surgical instrument detergents presently available contain some level of enzymes. The enzymatic enzyme surgical instrument detergent  industry is the largest single market for enzymes, at rate of 25 - 30% of total sales. Details of which enzymes are used within enzymatic enzyme surgical instrument detergents and the ways in which they are best used, are rarely been published.  Enzymatic enzyme surgical instrument detergents should: remove proteinaceous bioburden, dissolve mineral encrustation, remove stains, and enhance the “passive layer” of stainless steel. Enzymatic enzyme surgical instrument detergents should be “free rinsing” to render a residue free surface and should be designed to condition the source water to counter the potential pitting and staining effects of hard water. The primary goal of surgical instrument cleaning is to remove soil (proteinaceous bioburden) which includes proteins, starches and lipids.  This requires 4 enzymes ( Lipase Enzymes, Amylase Enzymes, Carbohydrase Enzymes and Protease Enzymes) for cleaning surgical instruments cleaner and faster with lower costs.
Define: enzyme detergent surgical instrument cleaners
Enzyme Detergent Enzymatic Detergent
Surgical Instrument Cleaners
Dosage rate claims as to the cleaning results promised from very small dosage rates of enzymatic enzyme detergent can be misleading. Due to the wide variance of potential applications, the only dosage rates that can be attributed to a level of enzymatic enzyme detergent cleaning performance are those dosage rates that have been observed within your facility to render the cleaning outcomes required. The optimal enzymatic enzyme detergent dosage rate (amount diluted per quantity of carrier solution, usually ounces per gallon of neutral pH water) is a function of the types of enzymes and the concentration level of enzymes within the enzymatic enzyme detergent product. Detergents can render inferior performance with higher levels of concentration. Enzymes can render better performance at higher levels of concentration. To determine the optimal (lowest dosage with highest cleaning result) amount of enzymatic enzyme detergent to use, begin with the dosage recommended by the manufacture and then titrate the dosage higher or lower based on your cleaning outcomes. The cost of enzymatic enzyme detergents products is reconciled by their performance and your cost benefit analysis will be reconciled by the savings in the quantity of enzymatic enzyme detergents used.
Define: enzyme detergent surgical instrument cleaners
Surgical Instrument Cleaners
Surgical Instrument Care  
The optimal application time for maximum enzymatic enzyme detergent cleaning performance depends of the level of soil hydration/encrustation, the amount of soil, and the mass of items being cleaned. Claims as to enzymatic enzyme detergent products “cleaning within minutes” are fallacious without specifics as to the above parameters. Types of enzymes potentially used within enzymatic enzyme detergents: Lipase Enzymes: (to breakdown fat) to cleave fatty acid residue from the glycerol residue in a neutral fat or a phospholipid. Amylase Enzymes: (to breakdown starch) to catalyze the hydrolysis of starch to sugar to produce carbohydrate derivatives. Carbohydrase Enzymes: (to breakdown starch to a lower level) to catalyze the hydrolysis of higher carbohydrates to lower forms. Protease Enzymes: (breakdown blood) including the proteinases and peptidases, to catalyze the hydrolytic breakdown of proteins. The use of enzymatic enzyme detergents allows lower temperatures and shorter periods of mechanical cleaning to be employed, often after a preliminary period of soaking. In general, enzyme detergents remove protein from clothes soiled with blood, milk, sweat, grass, etc. far more effectively than non-enzyme detergents. At present only proteases and amylases are commonly used. Although a wide range of lipases is known, it is only very recently that lipases suitable for use in detergent preparations have been deployed.
Define: enzyme detergent surgical instrument cleaners
Surgical Instrument Cleaners
Surgical Instrument Care 
Enzymatic enzyme detergent surgical instrument cleaners must be cost-effective and safe to use. Early attempts to use proteases floundered because users developed hypersensitivity. This was combated by developing dust-free granulates (about 0.5 mm in diameter) in which the enzyme is incorporated into an inner core, containing inorganic salts (e.g. NaCI) and sugars as preservative, bound with reinforcing, fibers of carboxymethyl cellulose or similar protective colloid. This core is coated with inert waxy materials made from paraffin oil or polyethylene glycol plus various hydrophilic binders, which later disperse in the wash. This combination of materials both prevents dust formation and protects the enzymes against damage by other detergent components during storage. It has been reported that spraying enzymatic enzyme detergent surgical instrument cleaning products has resulted in respiratory irritations. It is suspected that this is due to the enzyme aerosols. Applying the enzymatic enzyme detergent in a liquid of foam state should avoid this potential complication. 
Define: enzyme detergent surgical instrument cleaners
Surgical Instrument Cleaners
Surgical Instrument Care 
Surgical Instrument Cleaner with Conditioners 
product is used worldwide for cleaning surgical instruments cleaner.
This cleaner is 100% biodegradable and Neutral pH. This Surgical Instrument Cleaner complies with Surgical Instrument and Surgical Instrument Washer specifications. The enzymes used for enzymatic enzyme detergents are produced using species of Bacillus, mainly by just two companies. Novo Industri A/S produce and supply three proteases, Alcalase, from B. licheniformis, Esperase, from an alkalophilic strain of a B. licheniformis and Savinase, from an alkalophilic strain of B. amyloliquefaciens (often mistakenly attributed to B. subtilis). GistBrocades produce and supply Maxatase, from B. licheniformis. Alcalase and Maxatase (both mainly subtilisin) are recommended for use at 10-65°C and pH 7-10.5. Savinase and Esperase may be used at up to pH 11 and 12, respectively. The a-amylase supplied for detergent use is Termamyl, the enzyme from B. licheniformis which is also used in the production of glucose syrups. a-Amylase is particularly useful in washing glassware and with de-starching detergents.
Define: enzyme detergent surgical instrument cleaners
surgical instrument cleaners 
Enzymatic enzyme detergent surgical instrument cleaners, in a non-ionic surfactant, are available for formulating in liquid 'spotting' concentrates, and are typically used for removing stubborn stains. Preparations containing both Termamyl and Alcalase are produced. Termamyl is sufficiently resistant to proteolysis to retain activity long enough to fulfill its cleaning function. It should be noted that all the enzymatic enzyme detergent proteolytic enzyme surgical instrument cleaners described are non-specific serine endoproteases, giving preferred cleavage on the carboxyl side of hydrophobic amino acid residues but capable of hydrolysing most peptide links. They convert their substrates into small, readily soluble fragments which can be removed easily from fabrics. Only serine protease; may be used in enzymatic enzyme detergent formulations: thiol proteases (e.g. papain) would be oxidized by the bleaching agents, and metalloproteases (e.g. thermolysin) would lose their metal cofactors due to the reaction with the water softening agents or hydroxyl ions. There are opportunities to extend the use of enzymatic enzyme detergent surgical instrument cleaners. The recent availability of a suitable lipase may increase the quantities of enzymes employed. There are, perhaps, opportunities for enzymes such as glucose oxidase, lipoxygenase and glycerol oxidase as means of generating hydrogen peroxide in situ. Added peroxidases may aid the bleaching efficacy of this peroxide.
enzyme surgical instrument cleaners
Define: enzyme detergent surgical instrument cleaners

Define: enzyme detergent surgical instrument cleaners
A combination of enzyme cleaners and surfactant detergents are necessary for optimal surgical instrument cleaning. Enzyme Detergent surgical instrument cleaners are often referred to as all-in-one surgical instrument detergent enzyme lubricating cleaners. Surgical instrument cleaning enzymes are proteins produced by all living organisms that act as catalysts to speed up chemical reactions that would otherwise occur at a much slower rate. Catalysts delivered with the enzyme cleaners help the cleaning process from a beginning to an end. The enzyme catalysts are not used up in the reaction so they are available to help multiple reactions. Surgical instrument cleaning enzymes fit their target substrates like a lock fits a key. The surgical instrument cleaning enzymes active site is open only to specific target substances with a matching chemical and three dimensional shape. If the substrate doesn't fit, the surgical instrument cleaning enzymes can't enter and no cleaning reaction occurs. This makes the action of surgical instrument cleaning enzymes highly specific for their substrates. For this reason specific enzymes are needed for cleaning bioburden from surgical instruments. The four enzymes necessary for effective cleaning are: protease surgical instrument enzyme cleaners to breakdown proteins including blood, amylase surgical instrument enzyme cleaners to breakdown starch and catalyze the hydrolysis of starch, lipase surgical instrument enzyme cleaner to breakdown fats and high level lipids, and carbohydrase surgical instrument enzyme cleaner to breakdown high level starches. Enzyme detergents that do not offer these four enzymes cannot remove all forms of proteinaceous bioburden and will not be as effective for cleaning surgical instruments. When bioburden has been emulsified, i.e. during suction, the bioburden becomes more challenging to remove, particularly lipids and proteins. Highly concentrated protease enzyme cleaners and lipase enzyme cleaners are necessary.

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